Yearly Demand for Whole Human Genome Sequencing – 400K New Genomes in 2015 ?


(Figure courtesy of the National Human Genome Research Institute: 

Advances since the Human Genome Project ended in 2003 have been significant. With new Illumina sequencing instruments becoming operational in April, large facilities will be able to generate 18,000 whole human genomes (18,000 30x Genomes / HiSeq X Ten, a set of 10 HiSeq X Systems). As of today, these facilities include: the Broad Institute, Garvan Research Foundation, Macrogen, New York Genome Center, Novogene and WuXi PharmTech. At a rate of 1 genome / lane, this begs the question how many 30x human genomes will be sequenced in the next 3 years ? Let’s estimate that each facility will churn out around 25,000, 30x genomes/year (some of the facilities above have purchased multiple HiSeq X Tens, others have more than 10 daisy chained together). In 2015 yield from these facilities alone (assuming no one else purchased a machine) would be ~150,000 genomes. Optimistically doubling that to account for new HiSeq X Ten purchases between now and 2015 would give an estimate of ~300,000 genomes in 2015, and that’s only on the HiSeq X Ten. Assuming this year there will already be 60,000 30x (non-HiSeq X Ten) genomes sequenced, 20% growth brings this figure closer to ~400,000 genomes in 2015. While this figure certainly does not account for delays, instrument break downs, data analysis, storage and library prep bottlenecks, it represents optimistic potential for 2015.

The next question is who’s going to supply all the DNA ? Several new initiatives to sequence whole populations are quickly popping up. With £100m earmarked, the UK is planning on sequencing the genomes of up to 100,000 NHS patients by 2017 (instrument platform likely Illumina), Saudi Arabia also plans to map 100,000 of their citizens, with the Ion Proton in line ready to do all the heavy lifting: Craig Venter’s recent launch of the company Human Longevity plans to start sequencing 40,000 genomes with plans to “rapidly scale to 100,000 human genomes / year”:

Everything described above pertains to whole human genome sequencing and is not meant to undercut the significantly higher number of other species that will be sequenced between now and 2015. Our focus at Genohub is to make it easy for researchers interested in next generation sequencing services to access all the latest sequencing technology, including the HiSeq X Ten: Anyone can search for, find and order sequencing, library prep and analysis services, making owning an actual sequencing instrument not a requirement for getting access to good quality data.



The “$1K”, 30X Whole Human Genome is now available for $1,400

HiSeq X Ten Sequencing Services now Available on Genohub

You can now order whole human genome sequencing (~30x coverage) on for $1,400 / sample ($1,550 with library prep). The Kinghorn Centre for Clinical Genomics is accepting orders for their HiSeq X Ten service through  In fact, you can order this service today:

Designed for population scale human genome sequencing, the HiSeq X Ten when operating individually can output between 1.6-1.8 Tb on a dual flow cell in less than 3 days (600 Gb / day). When running 10 in parallel, tens of thousands of genomes can be sequenced in a single year. While currently Illumina has limited the HiSeq X Ten to human samples, we expect this will change in 2015. 

A single lane of HiSeq X Ten, gives you 750M paired end 2x 150 reads, for a total output of 112.5 Gb / lane. Kinghorn guarantees 100 Gb raw data per lane, with >75% of bases above Q30 at 2x150bp. With a haploid human genome size of 3.2 Gb, that’s equivalent to 30-35x  per lane of sequencing.  The $10 million price tag for the HiSeq X Ten means that not all institutes have access to such sequencing power. Genohub solves this problem by making it easy for researchers interested in next generation sequencing services to access all the latest sequencing technology. We also:

  1. Ensure your project with the provider goes smoothly
  2. Take care of billing and invoicing, making domestic & international ordering a breeze
  3. Have an easy to use project management interface to keep communication and information in one place
  4. Offer NGS project design and consultation
  5. Have competitive pricing and turnaround times

Start your population study on today !